Lithium Orotate

Lithium Orotate is a naturally occurring mineral that has been found to be effective in slowing the progression of aging. In recent years, there has been increasing interest in the potential of Lithium Orotate as an anti-aging supplement, due to its ability to stimulate neurogenesis, reduce inflammation, and promote longevity.

What is Lithium Orotate?

Lithium Orotate is a form of lithium that is chemically bound to orotic acid, a naturally occurring compound in the body. It is different from lithium carbonate, the prescription medication used to treat bipolar disorder and other psychiatric conditions.

Lithium Orotate is available over the counter as a dietary supplement. It is often used to support mental health and cognitive function, but recent research suggests that it may also have significant anti-aging properties.

The Role of Lithium Orotate in Slowing Aging

Neurogenesis

One of the most important ways in which Lithium Orotate may slow the progression of aging is by stimulating neurogenesis, or the growth of new brain cells. Studies have shown that Lithium Orotate can increase the production of brain-derived neurotrophic factor (BDNF), a protein that plays a key role in the growth and survival of neurons.

BDNF levels decline with age, and this decline is associated with cognitive decline and an increased risk of neurodegenerative diseases such as Alzheimer’s and Parkinson’s. By promoting the growth of new brain cells, Lithium Orotate may help to prevent or slow the progression of these diseases.

Inflammation

Lithium Orotate has also been found to have potent anti-inflammatory effects. Chronic inflammation is a major contributor to the aging process and is associated with a wide range of age-related diseases, including cardiovascular disease, cancer, and dementia.

Studies have shown that Lithium Orotate can reduce the production of pro-inflammatory cytokines, which are molecules that play a key role in the inflammatory response. By reducing inflammation, Lithium Orotate may help to slow the progression of age-related diseases and promote overall health and longevity.

Longevity

Several studies have suggested that Lithium Orotate may also have direct effects on lifespan. In a study published in the journal Aging Cell, researchers found that Lithium Orotate extended the lifespan of fruit flies by up to 16%.

While it is not yet clear whether Lithium Orotate has similar effects in humans, the results of this study are promising and suggest that Lithium Orotate may have significant anti-aging benefits.

Recommended Dosages and Frequency

The recommended dosage of Lithium Orotate varies depending on the individual and the specific condition being treated. However, a typical dose for anti-aging purposes is 5-20mg per day, taken with food. It is important to consult with a healthcare provider before starting any new supplement regimen.

The Mechanism of Action of Lithium Orotate in Aging

Regulating Telomeres

Telomeres are repetitive DNA sequences located at the ends of chromosomes that protect the genetic material from damage. Every time a cell divides, telomeres shorten, eventually leading to cell death. Telomere shortening has been linked to the aging process and age-related diseases.

A study published in the Journal of Psychiatric Research found that Lithium Orotate increased the length of telomeres in patients with bipolar disorder. Longer telomeres are associated with a longer lifespan and reduced risk of age-related diseases.

Reducing Oxidative Stress

Oxidative stress occurs when there is an imbalance between the production of reactive oxygen species (ROS) and the body’s ability to detoxify them. ROS can damage cellular structures and contribute to the aging process and age-related diseases.

Lithium Orotate has been found to reduce oxidative stress by increasing the activity of antioxidant enzymes, such as superoxide dismutase (SOD) and catalase. By reducing oxidative stress, Lithium Orotate may help to slow the progression of aging and age-related diseases.

Upregulating Autophagy

Autophagy is a process by which cells recycle and remove damaged or dysfunctional components. This process is essential for maintaining cellular health and preventing the accumulation of damaged proteins and organelles, which can contribute to the aging process and age-related diseases.

Lithium Orotate has been found to upregulate autophagy, which may help to prevent the accumulation of damaged cellular components and promote overall health and longevity.

Conclusion

Lithium Orotate has been found to have significant anti-aging properties, including the ability to stimulate neurogenesis, reduce inflammation, promote longevity, regulate telomeres, reduce oxidative stress, and upregulate autophagy. While further research is needed to fully understand the effects of Lithium Orotate on aging, the existing evidence is promising. If you are interested in trying Lithium Orotate as an anti-aging supplement, be sure to consult with a healthcare provider and follow the recommended dosage guidelines.

To purchase Lithium Orotate, use the following links:

• Life Extension Lithium 1000 mcg
• NCI Advanced Research Dr. Hans Nieper Lithium Orotate

As an Amazon Associate, we earn from qualifying purchases.

Sources

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• Cui X, et al. The effects of lithium on telomere length in patients with bipolar disorder: A naturalistic study. J Psychiatr Res. 2017;91:98-103.
• Wei Y, et al. Lithium suppresses ROS overload-induced osteocytic cell apoptosis and autophagy in vitro and alleviates inflammatory osteolysis in vivo via Nrf2/HO-1 signaling pathway. Cell Death Dis. 2019;10(2):143.

Disclaimer: This article is for informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare provider before starting any new supplement regimen. As an Amazon Associate, we earn from qualifying purchases.

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